个人简介博士研究生导师，首届龙江名医，教 授，主任医师，医学博士，药学博士后；暨南大学附属第一医院内分泌代谢科主任；中华医学会糖尿病学分会委员，Endocrine Reviews 中文版编委，中俄医科大学联盟内分泌代谢病学术委员会主任委员，美国内分泌学会委员，中华医学会糖尿病学分会流行病与预防学组委员，中华医学会内分泌学分会中西医结合学组委员，中华医学会糖尿病学分会微血管并发症学组委员，中国微循环学会糖尿病与微循环专业委员会委员，黑龙江省医学会内分泌分会副主任委员；主持国家自然科学基金2项，并主持教育部、科技部等课题共11项；以通讯作者或第一作者发表文章56篇；获省科学技术进步二等奖，省卫生厅科学技术进步一等奖，省科学技术进步三等奖，“院扶贫义诊先进个人”等称号。先后培养硕士研究生 34 名，博士研究生 13名，博士后 2 名，指导留学生 5 名。1名博士生获学业奖学金一等奖，3名学生生获国家奖学金。擅长使糖尿病患者临床治愈或缓解，减少并发症；对亚甲炎患者用“非激素疗法”、甲减或甲状腺眼病患者减少激素用量；擅长性腺、垂体、肾上腺等内分泌病的诊治。近3年连续主办以疑难病为主的国际学术会议，获同行肯定；2017年全国病例大赛我科医生获省前两名、全国第二名。学术任职中华医学会糖尿病学分会委员，Endocrine Reviews 中文版编委，中俄医科大学联盟内分泌代谢病学术委员会主任委员，美国内分泌学会委员，中华医学会糖尿病学分会流行病与预防学组委员，中华医学会内分泌学分会中西医结合学组委员，中华医学会糖尿病学分会微血管并发症学组委员，中国微循环学会糖尿病与微循环专业委员会委员，黑龙江省医学会内分泌分会副主任委员 主研方向本团队研究方向为胰岛素抵抗、糖尿病及心血管并发症的发病机制及防治。作为负责人承担国家自然科学基金2项，其他省部级课题11项。 获奖情况以第一完成人获省科学技术进步二等奖、省卫生厅科学技术进步一等奖、省科学技术进步三等奖；获中华医学会临床继续教育项目病例大赛省第一名、全国并列第一名；获院“优秀科技工作者”、院英语论文报告会优秀奖；院“扶贫义诊先进个人”称号。 学术论著 1. Yang F, Qin Y, Lv J, et al. Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy. Cell Death Dis. 2018 Sep 24;9(10):1000. (通讯作者) 2. Yang F, Li A , Qin Y, et al. A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA. Mol Ther Nucleic Acids. 2019 Jul17;17:636-643. （通讯作者） 3. Che H, Wang Y, Li H, Li Y, Sahil A, Lv J, Liu Y, Yang Z, Dong R, Xue H, Wang L. Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. FASEB J. 2020 Feb 17. doi: 10.1096/fj.201902692R. （通讯作者） 4. Yang F, Qin Y, Wang Y, et al. LncRNA KCNQ1OT1 Mediates Pyroptosis in Diabetic Cardiomyopathy. Cell Physiol Biochem. 2018;50(4):1230-1244. (通讯作者) 5. Zhou T, Meng X, Che H, et al. Regulation of insulin resistance by multiple miRNAs via targeting the GLUT4 signalling pathway. Cell Physiol Biochem. 2016;38(5):2063-78. (通讯作者) 6. Che H, Wang Y, Li Y et al. Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts. J Cell Physiol. 2019 Nov 11.(通讯作者) 7. Yang F, Qin Y, Wang Y, et al. Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. Int J Biol Sci 2019;15:1010-1019.DOI:10.7150/ijbs.29680. (通讯作者) 8. Wang Y, Li H, Li Y, et al. Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation. Phytother Res 2019.DOI:10.1002/ptr.6448.（通 讯作者） 9. Xian HM, Che H, Qin Y，et al. Coriolus versicolor aqueous extract ameliorates insulin resistance with PI3K/Akt and p38 MAPK signaling pathways involved in diabetic skeletal muscle. Phytother Res. 2018 Mar;32(3):551-560. (通讯作者). 10. Shen N, Li X, Zhou T, Bilal MU, et al. Shensong Yangxin Capsule prevents diabetic myocardial fibrosis by inhibiting TGF-β1/Smad signaling. J Ethnopharmacol. 2014 Nov 18;157:161-70. (通讯作 者) 11. Sheng X, Che H, Ji Q, et al. The Relationship Between Liver Enzymes and Insulin Resistance in 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease. Horm Metab Res. 2018 May;50(5):397-402. (通讯作者) 12. Li Q, Li Z, Lin Y et al. High glucose promotes hepatic fibrosis via miR-32/MTA3 mediated Epithelial-to-Mesenchymal Transition. Molecular Medicine Reports. (通讯作者) 13. Meng S, Yang F, Wang Y, Qin Y, Xian H, Che H, Wang L. Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF-β1/Smad signaling. Cell Biol Int. 2018 Nov 29. doi: 10.1002/cbin.11079. (通讯作者) 14. Fan Yang, Yongting Zhao, Jie Lv, Xia Sheng, Lihong Wang. A new compound heterozygous mutation in a female with 17α-hydroxylase/17,20-lyase deficiency, slipped capital femoral epiphysis and adrenal myelolipoma. Gynecological Endocrinology. (通讯作者) 15. Zhao Y, Yang F, Qiu L et al. A novel heterozygous intron mutation in SEMA7A causing kallmann syndrome in a female. Gynecol Endocrinol. 2019 Oct 25:1-4. (通讯作者) 16. Zhao Y, Yang F , Wang L et al. Familial hypophosphatemic rickets caused by a PHEX gene mutation accompanied by a NPR2 missense mutation. J Pediatr Endocrinol Metab. 2020 Jan 13. (通讯 作者) 17. Wang LH, Li XL, Li Q, Fu Y, et al. Berberine alleviates ischemic arrhythmias via recovering depressed Ito and Ica currents in diabetic rats. Phytomedicine. 2012 Feb 15;19(3-4):206-10. (第一作 者) 18. Wang LH, Yu CH, Fu Y, Li Q, Sun YQ. Berberine elicits anti-arrhythmic effects via IK1/Kir2.1 in the rat 2 diabetic myocardial infarction model. Phytother Res. 2011 Jan;25(1):33-7. doi: 10.1002/ptr.3097. (第一作者) 19. Ai J, Wang LH, Zhang R, et al. Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia. BMC Complement Altern Med. 2010 Dec 22;10:80. (第一作者) 20. Ai J, Zhang R, Li Y, et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun. 2010 Jan 1;391(1):73-7.[收起]